Disease of robo dwarf hamsters tagr9/11/2023 ![]() ![]() Vaccines are widely available 2, 3, but recuring global infection waves have been fueled by limited longevity of vaccine-induced immunity, the hesitancy of population subgroups to vaccinate 4, 5, and increasingly contagious and/or vaccine-insensitive variants of concern (VOC) alpha (B.1.1.7 lineage), beta (B.1.351 lineage), gamma (P.1 lineage), delta (B.1.617.2 lineage), and omicron (B1.1.529 lineage) 6, 7. The dwarf hamster model recapitulates mixed efficacy of molnupiravir in human trials and alerts that benefit must be reassessed in vivo as VOC evolve.īy May 2022, SARS-CoV-2 has resulted in over 522 million cases and >6.2 million deaths worldwide 1. Treatment effect size varied in individual dwarf hamsters infected with omicron and was significant in males, but not females. ![]() All molnupiravir-treated dwarf hamsters survived, showing reduction in lung virus load from one (delta) to four (gamma) orders of magnitude. Pathogenicity in dwarf hamsters was VOC-dependent and highest for delta, gamma, and omicron. Treatment reduced shedding in ferrets and prevented transmission. VOC were equally inhibited by molnupiravir in cells and organoids. This study evaluates molnupiravir against VOC in human airway epithelium organoids, ferrets, and a lethal Roborovski dwarf hamster model of severe COVID-19-like lung injury. Oral antivirals such as molnupiravir promise to improve disease management, but efficacy against VOC delta was questioned and potency against omicron is unknown. SARS-CoV-2 variants of concern (VOC) have triggered infection waves. ![]()
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